|
USA-NY-SALEM Κατάλογοι Εταιρεία
|
Εταιρικά Νέα :
- Phenotypic Screening of the Reframe Drug Repurposing Library to . . .
To this end, we have just completed a phenotypic screen of the 12,657 compounds of the Scripps ReFrame drug repurposing library using our recently developed high-throughput assay to measure sickling times following deoxygenation to 0% oxygen of red cells from individuals with sickle trait (HbAS), the heterozygous condition
- Correction for Metaferia et al. , Phenotypic screening of the ReFRAME . . .
Correction for Metaferia et al , Phenotypic screening of the ReFRAME drug repurposing library to discover new drugs for treating sickle cell disease Proceedings of the National Academy of Sciences of the United States of America ( IF 9 4) Pub Date : 2024-11-14, DOI: 10 1073 pnas 2421475121
- Phenotypic screening of the ReFRAME drug repurposing library to . . .
Our high-throughput phenotypic screen of the ReFRAME drug repurposing library reported here discovered 106 compounds that are antisickling On a statistical concentration basis, as many as 20 are predicted to be potential drugs
- Swee Lay Thein, B. S. , F. R. C. P. , F. R. C. Path. , D. Sc. , FMedSci
Phenotypic screening of the ReFRAME drug repurposing library to discover new drugs for treating sickle cell disease Proc Natl Acad Sci U S A 2022;119(40):e2210779119 Related Scientific Focus Areas
- Phenotypic screening of the ReFrame Drug Repurposing Library to . . .
Our high throughput phenotypic screen of the ReFrame drug repurposing library reported here discovered 107 compounds that are anti- sickling On a statistical concentration basis, as many as 20 are predicted to be potential drugs Abstract (250 words, maximum allowed is 250)
- Phenotypic screening of the ReFRAME drug repurposing library to . . .
Stem cell transplantation and genetic therapies offer potential cures for patients with sickle cell disease (SCD), but these options require advanced medical facilities and are expensive Consequently, these treatments will not be available for many years to the majority of patients suffering from
- Phenotypic Screening: A Powerful Tool for Drug Discovery
To identify an inexpensive oral drug for treating sickle cell disease, researchers performed a high-throughput phenotypic screen of the ReFRAME drug repurposing library This identified 106 compounds with antisickling activity
- Phenotypic screening of the ReFrame Drug Repurposing Library to . . .
Here we report results of the first phase of our phenotypic screen of the 12,657 compounds of the Scripps ReFrame drug repurposing library using a recently developed high-throughput assay to measure sickling times following deoxygenation to 0% oxygen of red cells from sickle trait individuals
- ReframeDB
High content, cell-based assay designed to identify compounds that modulate neuronal mitostasis This is a cell based phenotypic screen to find in the ReFRAME library compounds capable of inhibit growth of Entamoeba histolytica strain HM-I:IMSS The parasite expresses luciferase
- Phenotypic screening of the ReFRAME drug repurposing library to . . .
Phenotypic screening of the ReFRAME drug repurposing library to discover new drugs for treating sickle cell disease
|
|