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- Comprehensive morphologic characterization of bone marrow . . .
Diagnostic and follow-up bone marrow biopsy specimens from 52 male patients with molecularly identified VEXAS syndrome underwent central review Results: Cytopenias were common in all cases, primarily macrocytic anemia, monocytopenia, and thrombocytopenia
- Comprehensive morphologic characterization of bone marrow . . .
Diagnostic and follow-up bone marrow biopsy specimens from 52 male patients with molecularly identified VEXAS syndrome underwent central review Cytopenias were common in all cases, primarily macrocytic anemia, monocytopenia, and thrombocytopenia
- Histopathologic Characterization of Vexas Syndrome Free
VEXAS syndrome (vacuoles, E1 ubiquitin ligase, X-linked, autoinflammatory, somatic) is a newly recognized inflammatory disorder caused by somatic mutations in the UBA1 gene Bone marrows from these patients reveal a range of morphological changes in hematopoietic precursor cells
- Characteristic bone marrow findings in patients with UBA1 . . .
Hematologic abnormalities, particularly peripheral blood cytopenia (s) may prompt bone marrow evaluation in patients with known or unrecognized VEXAS syndrome This review highlights key findings and diagnostic considerations encountered during bone marrow examination in patients with this disorder
- Distinct bone marrow findings associated with a noncanonical . . .
The characteristic bone marrow (BM) finding in VEXAS syndrome is cytoplasmic vacuolization in myeloid and erythroid precursors, with relatively small, round, well-demarcated vacuoles (Figure 1A–C), which can be subtle in some cases 2 In addition, patients with VEXAS syndrome typically show a hypercellular BM with myeloid hyperplasia, which
- A case of VEXAS syndrome presenting with unusual bone marrow . . .
Here we report the first case of VEXAS with non-caseating granulomas in the bone marrow A 62-year-old Asian male presented with fevers, erythema nodosum, inflammatory arthritis, and periorbital inflammation Labs were significant for persistently elevated inflammatory markers and macrocytic anemia
- Characteristic bone marrow findings in patients with UBA1 . . .
Hematologic abnormalities, particularly peripheral blood cytopenia (s) may prompt bone marrow evaluation in patients with known or unrecognized VEXAS syndrome This review highlights key findings and diagnostic considerations encountered during bone marrow examination in patients with this disorder
- VEXAS Syndrome | NIAMS - National Institute of Arthritis and . . .
Patients with VEXAS may also have signs and symptoms consistent with a blood bone marrow disorder, including but not limited to: Anemia – low hemoglobin red blood cell count; Low platelets; Low white blood cell counts; Abnormal bone marrow biopsy findings (vacuoles)
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