- Human Leukocyte Antigen Gene Polymorphism and the . . .
The human leukocyte antigens (HLA) encoded by genes within the major histocompatibility complex display an impressive degree of polymorphism This variability is apparently maintained in human populations through the need to successfully display a
- Why does the HLA show a high degree of polymorphism?
There are multiple explanations for the enormous polymorphism in major histocompatibility complex (MHC -- the general term for the equivalent of HLA in all species) proteins In general they reflect resistance to infectious disease, with the details being mildly debated, and usually not mutually exclusive -- multiple reasons probably apply
- Human leukocyte antigen - Wikipedia
HLA genes are highly polymorphic, which means that they have many different alleles, allowing them to fine-tune the adaptive immune system The proteins encoded by certain genes are also known as antigens, as a result of their historic discovery as factors in organ transplants [3]
- Polymorphisms of HLA-B: influences on assembly and immunity
These genes are highly polymorphic, which results in the expression, typically, of six different HLA class I (HLA-I) proteins on the cell surface, and the presentation of diverse peptide antigens to CD8 + T cells for broad surveillance against many pathogenic conditions
- Hla gene - Everything you need to know
The Hla gene is highly polymorphic, meaning that it exists in many different forms, known as alleles This polymorphism allows for a wide range of antigen recognition and immune response capabilities, making humans more adaptable to diverse pathogens
- What Are HLA Haplotypes and Why Do They Matter?
The genes within this complex are inherited from both parents, contributing to each individual’s unique immune makeup These genes come in many different versions, or alleles The HLA system is one of the most polymorphic parts of the human genome, with an immense variety of alleles for each HLA gene
- The role of gene polymorphism in HLA class I splicing
The HLA genes are known for their high polymorphic density (Leffler et al , 2013), possibly due to the high evolutionary pressure of being able to present a diverse array of peptides (Sommer, 2005; Klitz et al , 2012) HLA polymorphism is mainly located in the peptide-binding groove, encoded by exons 2 and 3 for HLA class I, and determines the
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