- Platinum-based drugs in cancer treatment: Expanding horizons . . .
Molecular target and mechanism of action of platinum-based drugs to target identification (TID) in the early stages of drug discovery were showed The structures of platinum complexes in anti-cancer medications for the treatment of different types of cancer were explained
- Platinum-based drugs for cancer therapy and anti-tumor . . .
Pt-based nanodrugs, such as platinum nanoclusters, have novel anti-cancer mechanisms and great potential in tumor-targeted therapy and have shown promising results in clinical application In this review, we systematically explored the development of first-line platinum chemotherapy drugs in the clinic and their anti-cancer mechanisms
- Platinum Antitumor Complexes: 50 Years Since Barnett . . .
After experiences in the 1990s, when dose escalation of carboplatin with autologous bone marrow or peripheral blood stem-cell reconstitution failed to cure platinum-sensitive ovarian cancer (in contrast to some documented success in testicular cancer), attention shifted to identification of HRD as a surrogate for platinum sensitivity
- Scientists and clinicians test their metal–back to the future . . .
Recent information on drug-efflux pathways, including expression of multidrugresistance protein 2, and on how tumour cells behave when their DNA is distorted by a platinum adduct, suggests new avenues for translational research
- Platinum Compounds: Innovations in Cancer Treatment and . . .
By incorporating axial ligands such as carboxylates, researchers have developed platinum (IV) derivatives with improved pharmacokinetics and tumor selectivity Platinum-based compounds exert cytotoxic effects by forming covalent bonds with DNA, disrupting replication and transcription
- 11. 6. 5: Platinum Anticancer Drugs- A Case Study
In addition to testicular cancer, platinum chemotherapy has produced responses in patients with ovarian carcinomas (>90 percent), head and neck cancers, non-small-cell lung cancer, and cervical cancer
- Metals in Cancer Research: Beyond Platinum Metallodrugs
The clin success of platinum-based chemotherapeutic agents was of enormous impact on the discovery of novel metal N-heterocyclic carbene (NHC) complexes as potential anti-cancer drugs During the last years, the research on cytotoxic transition metal (e g Ag, Au, Pt, Pd, Cu, Hg, Ru, Os, Rh and Ir) NHC complexes was successful and the results
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