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- The SOFA score—development, utility and challenges of accurate . . .
The Sequential Organ Failure Assessment or SOFA score was developed to assess the acute morbidity of critical illness at a population level and has been widely validated as a tool for this purpose across a range of healthcare settings and environments In recent years, the SOFA score has become extensively used in a range of other applications A change in the SOFA score of 2 or more is now a
- Evaluation of SOFA-based models for predicting mortality in the ICU: A . . .
Introduction To systematically review studies evaluating the performance of Sequential Organ Failure Assessment (SOFA)-based models for predicting mortality in patients in the intensive care unit (ICU) Methods Medline, EMBASE and other databases were searched for English-language articles with the major objective of evaluating the prognostic performance of SOFA-based models in predicting
- Prehospital lactate analysis in suspected sepsis improves detection of . . .
Background Rapid, adequate treatment is crucial to reduce mortality in sepsis Risk stratification scores used at emergency departments (ED) are limited in detecting all septic patients with increased mortality risk We assessed whether the addition of prehospital lactate analysis to clinical risk stratification tools improves detection of patients with increased risk for rapid deterioration
- Lymphocyte count trajectories are associated with the prognosis of . . .
The distinct lymphocyte trajectories might imply different immune profiles and outcomes in sepsis Trajectory 1, with initially high lymphocyte counts, was associated with elevated SIRS scores and 7-day mortality, possibly reflecting a pro-inflammatory sepsis phenotype
- A multicentre prospective registry of one thousand sepsis patients . . .
Background Sepsis is a global health problem with high morbidity and mortality Low- and middle-income countries have a higher incidence and poorer outcome with sepsis Large epidemiological studies in sepsis using Sepsis-3 criteria, addressing the process of care and deriving predictors of mortality are scarce in India Method A multicentre, prospective sepsis registry was conducted using
- Novel cortisol trajectory sub-phenotypes in sepsis
Background Sepsis is a heterogeneous syndrome This study aimed to identify new sepsis sub-phenotypes using plasma cortisol trajectory Methods This retrospective study included patients with sepsis admitted to the intensive care unit of Zhongshan Hospital Fudan University between March 2020 and July 2022 A group-based cortisol trajectory model was used to classify septic patients into
- Validation of CLIF-C ACLF score to define a threshold for futility of . . .
Background Acute-on-chronic liver failure (ACLF) is a severe complication of cirrhosis and is defined by organ failure and high rates of short-term mortality Patients with ACLF are managed with multiorgan support in the intensive care unit (ICU) Currently, it is unclear when this supportive care becomes futile, particularly in patients who are not candidates for liver transplant The aim of
- Impact of the timing of invasive mechanical ventilation in patients . . .
Background The potential adverse effects associated with invasive mechanical ventilation (MV) can lead to delayed decisions on starting MV We aimed to explore the association between the timing of MV and the clinical outcomes in patients with sepsis ventilated in intensive care unit (ICU) Methods We analyzed data of adult patients with sepsis between September 2019 and December 2021 Data
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