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- Nephrogenic Factors Promote Differentiation of Mouse . . .
This study used a combination of nephrogenic growth factors to differentiate ES cells into renal epithelial cells that are capable of integrating into a developing kidney with very high
- TISSUE-SPECIFIC PROGENITOR AND STEM CELLS
In the present re-view, we provide an overview of the native nephrogenic niche, describing the complex signals that allow survival and maintenance of undifferentiated renal stem progenitor cells and the stimuli that promote differentiation
- Recapitulating kidney development in vitro by priming and . . .
Here, we improved on existing mouse differentiation protocols by eliminating the use of embryoid bodies and developing a monolayer protocol that generates multiple renal progenitor cell types,
- INVESTIGATING THE NEPHROGENIC POTENTIAL OF MOUSE EMBRYONIC . . .
INVESTIGATING THE NEPHROGENIC POTENTIAL OF MOUSE EMBRYONIC STEM CELLS AND THEIR DERIVATIVES Thesis submitted in accordance with the requirements of the University of Liverpool for the degree of Doctor in Philosophy by Aleksandra Rak-Raszewska October 2010 i
- 3D Culture Supports Long-Term Expansion of Mouse and Human . . .
Li et al report the derivation and long-term culture of mouse and human nephron progenitor cell lines under chemically defined conditions in 3D format Expanded NPCs have nephrogenic potential in vitro and in vivo and allow the study of kidney organogenesis, gene editing, drug screening, and disease modeling
- Embryonic Renal Epithelia: Induction, Nephrogenesis, and Cell . . .
Nephrogenesis implies a highly controlled series of morphogenetic and differentiation events that starts with reciprocal inductive interactions between two different primordial tissues and leads, in one of two mainstream processes, to the formation of mesenchymal condensations and aggregates
- Directed Differentiation of Pluripotent Stem Cells into Kidney
The identification of specific markers of the diferentiation process is critical to the development of protocols that efectively recapitulate nephrogenesis in vitro In this review, we summarize the current studies describing the diferentiation of ESCs and iPSCs into cells of the kidney lineage
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