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- Benzyl Protection - Benzyl Bromide - Common Organic Chemistry
To a solution of the SM (10 0 g, 99 0 mmol) in ACN (300 mL) was added K2CO3 (39 4 g, 285 mmol) and BnBr (41 0 mL, 346 0 mmol) The reaction mixture was stirred at reflux for 3 h
- Organic Reaction Workup Formulas for Specific Reagents
DMF or DMSO: Very polar and high-boiling solvents that are difficult to remove If your product is not dangerously polar, dilute with lots and lots of water before extracting with a nonpolar solvent
- K2CO3 CS2: A mild and effiecint system for the prapartion of . . .
I Amini et al Journal of Medicinal and Chemical Sciences Communication a Table 2 Synthesis of trithiocarbonate derivatives (according to Scheme 2) a Reaction conditions: 3 mmol of halide, 4 mmol of CS2 , 4 mmol of K2CO3, 5 mL of DMF, 40 oC in air b Isolated yields
- Benzyl Ethers - Organic Chemistry Portal
Benzyl ethers can by generated using the Williamson Ether Synthesis, for example, where initial deprotonation of the alcohol and subsequent reaction with benzyl bromide delivers the protected alcohol
- Workup: DMF or DMSO - University of Rochester
Workup for Reactions in DMF or DMSO DMF and DMSO are very polar and high-boiling solvents that are difficult to remove If your product is not dangerously polar, dilute with lots and lots of water before extracting with a nonpolar solvent Then thoroughly wash the organic layer with water
- Chem365 Labbook-2014 - Minnesota State University Moorhead
Scheme 2 Part B: Addition and reaction of Benzyl Bromide 6 Add K2CO3: Add 20 mmol of potassium carbonate powder (K2CO3, 0 139g mmol) through a powder funnel
- Benzyl (Bn) Protective Group - Chem-Station Int. Ed.
Experimental Procedure -The substrate is reacted with BnCl or BnBr in DMF with NaH as a base Benzylated products are generally obtained in high yield -The catalytic addition of Bu 4 NI (TBAI) or NaI accelerates benzylation (through in situ formation of reactive BnI) Experimental Tips -Benzyl bromide is a lachrymator Handle it inside a fume
- Substitution (Br) - Aliphatic Amines - Common Organic Chemistry
A solution of the alkyl bromide (B) (137 mg, 0 715 mmol) in DMF (0 5 mL) was added to a solution of the amine (A) (172 mg, 0 397 mmol) and K2CO3 (110 mg, 0 794 mmol) in DMF (2 5 mL) at RT
- Benzyl Protection in Organic Chemistry
Benzyl protection is typically performed using benzyl bromide (BnBr) or benzyl chloride (BnCl) in the presence of a base [1] [2] Catalytic hydrogenolysis it the most common method of benzyl deprotection Typical solvents include (MeOH, EtOH, EtOAc, and THF) [1] [2] 1) Kocienski, P J ; Protecting Groups, 3rd Edition
- Complications from Dual Roles of Sodium Hydride as a Base and as a . . .
This study identifies and characterizes these byproducts formed when sodium hydride is used with benzyl bromide in dimethylformamide (DMF) and acetonitrile The unintended side reactions, often overlooked in the literature, result from DMF involvement, specifically the generation of dimethylamine
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