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USA-NY-PLATTSBURGH Κατάλογοι Εταιρεία
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Εταιρικά Νέα :
- Interferon stimulated binding of ISRE is cell type specific . . .
We found that bound ISRE in promoters were shared across cell types at higher levels (41 %-92 %) than in enhancers regions (6 %-31 %) Overall, these results demonstrate that a substantial portion, if not a majority, of ISGF3 binding occurs on ISRE in enhancer elements
- Modification of enhancer chromatin: what, how and why? - PMC
Enhancers are enriched for H3K4me1, whereas high levels of H3K4me3 predominantly mark promoters These differences can be largely explained by the underlying differences in DNA sequence, with high CpG island density observed at most promoters, but not at enhancers
- Characterization and Prediction of ISRE Binding Patterns . . .
We nd that ISRE binding is cell speci c, particularly for ISREs distal to transcription start sites, potentially associated with enhancer elements, while ISRE binding in promoter regions is more conserved
- Regulatory regions in DNA: promoters, enhancers, silencers . . .
Certain regions, called cis-regulatory elements, on the DNA are footprints for the trans-acting proteins involved in transcription, either for the positioning of the basic transcriptional machinery or for the regulation - in simple terms turn on or turn off - thereof
- Making connections: enhancers in cellular differentiation
Enhancers, by contrast, are short (100–1000 bp) cis-regulatory genomic regions that can activate or enhance basal transcription from a target promoter They are characterised by a number of features, including open chromatin, specific histone modifications (H3K4me1, H3K27ac), and the binding of tissue-specic transcription factors [1 –3] (Box 1)
- 16. 4. 2: Transcriptional Enhancers and Repressors - Biology . . .
Transcriptional repressors can bind to promoter or enhancer regions and block transcription Like the transcriptional activators, repressors respond to external stimuli to prevent the binding of activating transcription factors
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