Hallmarks of Cancer: The Next Generation - ScienceDirect The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease
每10年一版的“Hallmarks of Cancer”牛文指引肿瘤研究热点 第二版“Hallmarks of Cancer” 2011年,由Douglas Hanahan和Robert A Weinberg共同撰写,发表在 Cell 上的“Hallmarks of cancer: the next generation”一文在第一版六大特征的基础上又增加了两个新标志,即 能量代谢的重新编程 和逃避免疫破坏(图2)。
泰斗级论文《Hallmarks of Cancer》。这是癌症领域的基础 . . . 今天咱们尝试理解这篇在肿瘤研究领域具有里程碑意义的论文——《Hallmarks of Cancer: The Next Generation》。 这篇论文由两位泰斗级科学家 Douglas Hanahan 和 Robert A Weinberg 于2011年发表在顶级期刊《Cell》上。
Hallmarks of Cancer: The Next Generation - 百度学术 The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease
文献分享 | Cell:Hallmarks of Cancer: The Next Generation Abstract: The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease
Hallmarks of Cancer: The Next Generation - Cell Press The hallmarks of cancer comprise six biological capabilities acquired during the multistep develop-ment of human tumors The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease
Hallmarks of cancer—Then and now, and beyond: Cell This review presents a concise synthesis of the hallmark conceptualization as it has been refined during the past 25 years, including a corollary hypothesis that mechanism-guided hallmark co-targeting could offer impactful new therapeutic strategies for treating human cancers
Cell综述:Hallmarks of Cancer: The Next Generation - 知乎 在本综述的第一部分中,我们总结了2000年原始演示文稿中描述的每个标志的本质,然后是过去十年在理解其机制基础方面取得的概念进展的精选插图(用斜体小标题划定)。 在随后的章节中,我们将讨论扩大概念化范围的新发展,依次描述对获得六个标志能力至关重要的两个使能特征,两个新出现的标志能力,对癌症表型至关重要的肿瘤微环境的构成和信号相互作用,我们最终讨论了这些概念的治疗应用的新前沿。 图1癌症的特征:这张图包含了我们 2000 年最初提出的六种标志性功能。 在过去的十年中,在理解每个标志的机制基础方面取得了显着进展。 可以说,癌细胞最基本的特征涉及它们维持慢性增殖的能力。
《癌症的标志》系列综述简介 - 知乎 2011年,针对癌症最新进展,两人对2000年发表的综述进行了修改、升级,并增加了4类新的特征,以《癌症的标志:新一代》(Hallmarks of Cancer: The Next Generation)发表在《细胞》(Cell)杂志上,文中,首先对原先发表于2000年综述中的6类癌症标志进行了修订: